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Pharmaceutical Raw Materials Secnidazole 99% CAS 3366-95-8 Used As Antiprotozoan Agent
Secnidazole belongs to category of antiprotozoal agents drugs. Secnidazole is a type of potentiate anticoagulant effect of warfarin. concurrent disulfîram may cause antabuse-like effects cimetidine prolongs half-life.
It belongs to 5 nitroimidazole, effective in intestinal ameobiasis, giardiasis, trichomoniasis or bacterial vaginosis with a single once only dose.
Secnidazole is a nitroimidazole anti-infective. Effectiveness in the treatment of dientamoebiasis has been reported. It has also been tested against Atopobium vaginae. This drug is commonly sold as Brand Name Flagentyl.
Secnidazole has the advantage of being a single dose treatment and in humans treated with a single dose of secnidazole (30 mg/kg), it achieved up to 98% cure. Researchers, in a comparative study between secnidazole and metronidazole found a curative rate of 100% for secnidazole and 96% for metronidazole. However, when metronidazole was used in a single dose, its curative rate was reduced to 36–54%. On the other hand, a single dose of secnidazole reaches the same response achieved with multiple dosage regimens of metronidazole or tinidazole.
Side Effects of Secnidazole:Nausea, epigastric pain, glossitis, fatigue, head ache, loss of appetite, diarrhea stomatitis, urticaria rash & leucopenia.
|Appearance||Creamy white crystalline powder, having slight characteristic odor|
|UV Absorbance||469-491 AT 391 nm|
A. Positive acid & alkaline chromogenic reaction
B. Max 319nm
C. Matches with standard
|Clarity of alcohol solution||2%W/V in ethanol solution be clear|
|Solubility||Soluble in water,freely soluble in methanol ,ethanol and glacial acetic acid,slightly soluble in ether|
|Residue on ignition||≤ 0.1%|
|Heavy metals||≤ 10ppm|
|Residual solvent||Ethyl acitate≤1000ppm|
|Any other individual impurity≤0.5%|
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