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Pharmaceutical Raw Materials CAS 6157-87-5 Trestolone Acetate for Treatment of Hyperplasia of Prostate and Bodybuilding
Chemically speaking, trestolone acetate(MENT) actually an alright looking drug. It doesn’t show much interaction with Sex Hormone Binding Globulin, which means that a good portion ought to stay unbound and active in the blood. Also, the drug is a potent binder to the androgen receptor, while showing minimal affinity for the progesterone and mineralocorticoid receptors respectively. Since it is not able to be 5a-reduced into a dihydro-version, it likely wouldn’t cause many of the side effects commonly associated with Dihydrotestosterone. This is also a likely reason that it is less apt to cause prostate enlargement, and may even be indicated for the treatment of specific prostate issues.
The ability of 7 alpha-methyl-19-nortestosterone acetate (MENT) to increase the weights of ventral prostate and seminal vesicles of castrated rats was four times higher than that of testosterone, while its effect on the weights of bulbocavernosus plus levator ani muscles (muscle), was 10 times that of testosterone.
Various forms of MENT in human pharmaceutical preparations and devices for contraception and hormone therapy, specifically MENT Ac implant and MENT transdermal gel and patch formulations, are currently under clinical investigation. MENT is absorbed transdermally up to three times the rate of testosterone - 17 methyl testosterone and 17-α methyl testosterone.
MENT will have application in a wide range of indications beyond androgen replacement therapy and contraception, including, without limitation, primary hypogonadism, testicular failure, ASIH, baldness, sarcopenia, loss of bone mass, muscle wasting and cachexia, BPH, prostate cancer and of course, bodybuilding and sports performance enhancement.
Trestolone acetate is the chemical name of active ingredient in MENT. MENT is a registered trademark of Population Council, Inc. in the United States and/or other countries.
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