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Anti Estrogen Steroids Trilostane 99% Vetoryl CAS 13647-35-3 for Breast Cancer Treatment
|CAS Registry Number||13647-35-3|
|Boiling point||497.8°C at 760 mmHg|
|Vapour Pressur||5.39E-12mmHg at 25°C|
Trilostane is used in the treatment of Cushing's syndrome. It is normally used in short-term treatment until permanent therapy is possible.
Trilostane blocks an enzyme involved in the production of several steroids including cortisol. Inhibiting this enzyme inhibits the production of cortisol. In Cushing's syndrome, the adrenal gland overproduces steroids. Although steroids are important for various functions of the body, too much can cause problems. Trilostane reduces the amount of steroids produced by the adrenal gland.
Trilostane produces suppression of the adrenal cortex by inhibiting enzymatic conversion of steroids by 3-beta-hydroxysteroid dehydrogenase/delta 5,4 ketosteroid isomerase, thus blocking synthesis of adrenal steroids.
Side effect:Symptoms of overdose include darkening of skin, drowsiness or tiredness, loss of appetite, mental depression, skin rash, and/or vomiting.
|Melting point||257°C to 270°C||261°C -266°C|
|Appearance||White to pale white solid||White solid|
|Heavy metals||No more than 20ppm||10ppm|
|Loss on drying||Not more than 0.5%||0.18%|
|Residue on Ignition||Not more than 0.1%||0.02%|
|Solubility||soluble in dimethyl sulfoxide||Conforms|
|soluble in pyridine||Conforms|
|slightly soluble in ethanol||Conforms|
|slightly soluble in water||Conforms|
|Assay (microbial)||Not less than 99.0%||99.5%|
|Related impurities||not more than 1.0%||0.35%|
|HPLC purity||not less than 99.0%||99.6%|
|Conclusion||Comply with In-house standard.|
|Storage||Store protected from light and moisture|
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